Advantage of Microdosing GLPs

About this video

In this short clip, the speaker argues that GLP-1 medicines are not meant to simply be stopped, and suggests microdosing instead to find a level where weight stays off on less medication. The speaker warns that cycling on and off can worsen body composition, because, the speaker says, regained weight is fat rather than the lean mass lost, so anyone coming off needs a game plan or bridging plan.

Key takeaways

• The speaker argues against simply stopping GLP-1 medicines and suggests microdosing as an alternative to discuss.
• The speaker warns that repeated on-off cycles can shift body composition toward less lean mass and more fat.
• The speaker says coming off a GLP-1 needs a planned alternative to keep weight off.

Episode details: published September 24, 2026 · 38.2K views · 1:10 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

← Previous: Best Tools for Gut Health & Weight Loss | Dr. Chris Thompson · Next: Essentials: Optimal Protocols to Build Strength & Grow Muscles | Dr. Andy Galpin →

All Andrew Huberman videos · Andrew Huberman profile · Huberman Lab (official site)