Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

About this video

Huberman speaks with Dr. Melissa Ilardo, an expert in human genetics and epigenetics, about how behaviour and environment modify gene expression. Dr. Ilardo says researchers are still learning how much of our DNA is modifiable, and that while some traits are written in our genes, far more appears changeable than once assumed. The episode explores the mammalian dive reflex in depth: Dr. Ilardo explains that in the divers she studied, larger spleens and higher red blood cell counts were linked to higher-than-average thyroid hormone levels, through a mechanism independent of erythropoietin, and that mouse work replicated the pattern. Huberman and Dr. Ilardo discuss possible performance and immune implications while stressing much remains unknown. They also cover mate selection based on smell and immune-system difference, how external traits can signal organ and hormone differences, and the current state and ethics of human gene editing, which Huberman notes is now possible and happening.

Key takeaways

• Dr. Ilardo says how much gene expression behaviour can modify is still being learned, but appears greater than once assumed.
• Dr. Ilardo links larger spleens and higher red blood cell counts in divers to higher-than-average thyroid hormone levels.
• Dr. Ilardo describes mouse work replicating the divers’ pattern without changes in erythropoietin.
• Huberman explains mate choice by smell tends to favour immune systems most different from one’s own.
• Huberman and Dr. Ilardo discuss the ethics of human gene editing as an increasingly important topic.

Episode details: published May 26, 2025 · 311.4K views · 1:52:11 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

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