Controlling Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Podcast #64

About this video

Huberman discusses how the nervous system regulates sugar intake and seeking, and how sugar regulates the nervous system, through two mechanisms: the sweet taste itself, which is rewarding and makes people want more sweet substances and even more of other foods, and the nutritive content of sugar, which acts independently of sweetness at a subconscious level. He describes post-ingestive effects taking about 15 minutes. Huberman explains that neuropod cells in the gut, discovered by Professor Diego Bohórquez at Duke University, respond to sugar in the gut and send electrical signals through the vagus nerve to the nodose ganglion and the nucleus of the solitary tract, and also trigger dopamine pathways in the mesolimbic reward system. He argues this parallel pathway explains why animals and humans come to prefer sugar-containing foods even when they cannot perceive their sweetness.

Key takeaways

• Huberman distinguishes sugar’s sweet taste effects from its subconscious nutritive effects.
• Huberman describes neuropod cells in the gut sensing sugar and signalling via the vagus nerve.
• Huberman says gut sugar signals trigger dopamine in the mesolimbic reward pathway.
• Huberman notes post-ingestive rewarding effects of sweet foods take about 15 minutes.
• Huberman explains blood glucose that is too low can impair neuron function.

Episode details: published March 21, 2022 · 1.5M views · 1:58:56 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

← Previous: Using Salt to Optimize Mental & Physical Performance | Huberman Lab · Next: Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance →

All Andrew Huberman videos · Andrew Huberman profile · Huberman Lab (official site)