Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

About this video

Huberman revisits his discussion with Dr. Kyle Gillett on male hormone optimisation. Gillett recommends monitoring development and hormone status across the lifespan, like diagnostic work on a new car, with follow-up blood work decided with a physician, usually about every 6 months. He explains SHBG as the protein that binds androgens and estrogens, and says testing should include testosterone with SHBG or free testosterone, and attention to DHT. On lifestyle, Gillett discusses diet and exercise, sleep in puberty, dairy and IGF-1 for growth, and adequate vitamin D for testosterone production and bone. He describes L-carnitine as a shuttle into mitochondria that, he says, also increases androgen-receptor density, and discusses boron, which he says can acutely lower high SHBG at 5 to 12 mg per day, as he presents it. The episode also covers prostate-related dosing he mentions, hair-loss drugs acting through DHT, and topical anti-androgens such as ketoconazole and caffeine, with cautions about systemic absorption of some topical options.

Key takeaways

• Dr. Gillett recommends lifespan hormone monitoring, with blood-work follow-up decided with a physician.
• Gillett explains SHBG as binding androgens and estrogens, limiting free hormone availability.
• Gillett discusses vitamin D, diet, exercise and sleep as foundations for hormone status.
• Gillett describes L-carnitine as a mitochondrial shuttle that he says increases androgen-receptor density.
• Gillett discusses boron for high SHBG and cautions that some topical hair-loss options are systemically absorbed.

Episode details: published July 2, 2026 · 147.1K views · 36:18 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

← Previous: Movement Practice to Strengthen Your Mind-Body Connection | Ido Portal · Next: Raising a Dog & Mastering Calm Assertive Energy | Cesar Millan →

All Andrew Huberman videos · Andrew Huberman profile · Huberman Lab (official site)