How to Optimize Cognitive Function & Brain Health | Dr. Mark D'Esposito

About this video

Neurologist Dr. Mark D’Esposito explains the brain mechanisms of executive function and working memory, and how cognition can be optimised or restored after injury and disease, including traumatic brain injury, concussion, Alzheimer’s, Parkinson’s and attention deficit disorders. D’Esposito emphasises dopamine’s role as a balance rather than a simple quantity: dopamine in the prefrontal cortex promotes stability of information held in mind, while dopamine in the basal ganglia allows updating and flexibility, so too much in either system produces rigidity or distractibility. He argues that no blood test can accurately report a person’s brain dopamine or serotonin levels, that imaging is the clinical route, and that behavioural tasks such as working memory span can serve as proxies for dopamine function.

Key takeaways

• Dr. D’Esposito explains executive function and working memory as inseparable parts of cognition.
• Dr. D’Esposito describes dopamine as a balance between prefrontal stability and basal ganglia flexibility.
• Dr. D’Esposito argues no blood draw can accurately measure brain neurotransmitter levels.
• Dr. D’Esposito says working memory performance can act as a behavioural proxy for prefrontal dopamine.

Episode details: published February 19, 2024 · 510.9K views · 2:32:38 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

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