Supplements for Longevity & Their Efficacy | Dr. Peter Attia

About this video

Huberman hosts Dr. Peter Attia, a physician focused on healthspan and lifespan, to evaluate supplements and related compounds for longevity. A major focus is the NAD pathway. Dr. Attia discusses approaches to increasing NAD, including intravenous NAD, oral precursors such as NR and NMN, and why oral NAD itself breaks down in the gut. He states his view that these approaches generally increase NAD levels in blood without a large practical difference between them. Dr. Attia shares his personal experience taking NR in capsule form and NMN sublingually, and describes intravenous NAD infusions as producing intense early sensations he experienced, including a feeling like a boot stepping on his chest, leg cramps, and nausea. Huberman frames Dr. Attia as systematically reviewing research literature and clinical trials while maintaining a clinical practice, making the episode an efficacy-focused appraisal rather than a simple endorsement of longevity supplements.

Key takeaways

• Dr. Attia discusses NR, NMN, and intravenous NAD as approaches to increasing NAD levels.
• Dr. Attia states his view that these NAD approaches do not differ greatly in their end effect on blood NAD.
• Dr. Attia describes strong physical sensations he experienced during NAD infusions.
• Huberman frames Dr. Attia’s approach as systematically reviewing trials and clinical evidence for each compound.
• The episode evaluates supplement efficacy for healthspan and lifespan rather than assuming benefit.

Episode details: published July 29, 2024 · 367.7K views · 2:30:42 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

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