The Science & Treatment of Bipolar Disorder

About this video

Huberman discusses bipolar disorder, describing massive, maladaptive shifts in energy, perception and mood that can damage the person and those around them. He states that people with bipolar disorder are at 20 to 30 times greater risk of suicide, and he also covers major depression, which he says up to 20% of people will experience, plus the neuroplasticity underlying mood regulation. Much of the episode traces lithium. Huberman recounts John Cade’s 1949 paper in the Medical Journal of Australia on lithium for what was then called psychotic excitement, and he explains that lithium requires careful blood monitoring, especially in the first three months, because of toxicity. Huberman also argues lithium was slow to reach patients partly because, as a naturally occurring element, it could not be patented, and the FDA did not allow its use for manic bipolar disorder until 1970.

Key takeaways

• Huberman describes bipolar disorder as maladaptive shifts in mood, energy and perception.
• Huberman states people with bipolar disorder face a 20 to 30 times greater suicide risk.
• Huberman explains lithium levels must be monitored carefully in blood because of toxicity.
• Huberman recounts that lithium was not allowed by the FDA for manic bipolar disorder until 1970.
• Huberman urges anyone suspecting bipolar disorder to speak with a qualified health professional.

Episode details: published July 25, 2022 · 1.4M views · 2:19:41 long. Summary written by Self Growth Videos from the episode itself. The science and protocols described are Andrew Huberman’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices.

← Previous: The Biology of Taste Perception & Sugar Craving | Dr. Charles Zuker · Next: Tools for Setting & Achieving Goals | Dr. Emily Balcetis →

All Andrew Huberman videos · Andrew Huberman profile · Huberman Lab (official site)