Watch This Before You Take NAD+

About this video

In a longer companion to her shorter NAD warning, Yurth argues IV NAD and popular precursors are, in her view, wasteful and potentially unsafe when used continuously. She contends NAD is compartmentalised inside cells, so blood measurements may not show what matters, and that infused NAD must be broken down before entering cells. She again blames raised degrading enzymes, especially CD38, for age- and illness-related decline, and claims excess precursor use can strain methylation, raise homocysteine in her account, and generate breakdown products she links to cardiovascular risk. Her alternative is to focus on blocking degradation, use simpler precursors only periodically if at all, and apply a do-no-harm standard.

Key takeaways

• Question whether a blood level reflects levels inside the cell nucleus, Yurth urges
• Yurth argues degradation, not reduced production, mainly drives NAD decline
• Consider methylation costs before using high amounts of precursors
• Apply a do-no-harm test when evidence is incomplete, she recommends

Episode details: published August 9, 2025 · 3.3K views · 7:55 long. Summary written by Self Growth Videos from the episode itself. The longevity and peptide concepts described are Dr. Elizabeth Yurth’s, presented for education — not medical advice. Consult a qualified professional before changing your own health practices. Disclosure: Dr. Yurth is co-founder and Chief Medical Officer of the Boulder Longevity Institute, a clinic, and BLI Academy sells clinician education.

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